抗癌抗生素金霉酸族包括三个化合物:光神霉素(金霉酸),色霉素 A_3及橄榄霉素 A。它们在许多国家用于癌的化疗。但是,由于这些化合物毒性太大,特别是对于胃肠道的毒性,因而临床应用受到限制。最近报道,橄榄霉素 A(1)及色霉素 A_2(2)的异丁基及色霉素 A_3的乙酰基解离后的产物仍保持它的抗癌活性,这些化合物糖上的某些转化与其抗癌活性 The anticancer antibiotic acid family consists of three compounds: mithramycin (aureobasidin), chromomycin A_3 and dalterelin A. They are used in cancer chemotherapy in many countries. However, due to the toxicity of these compounds is too large, especially for the gastrointestinal tract, so the clinical application is limited. Recently, it was reported that the products of the separation of the acetyl groups of metylamine A (1), chloramphenicol A_2 (2) and acetyl group of chloramphenicol A_3 retain their anti-cancer activity. Some of these compounds Transformation and its anticancer activity