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目的:研究足月新生儿高胆红素血症的发生因素、治疗方法及预后情况。方法:对2004年4月～2007年5月该院儿科收治的169例高胆红素血症足月新生儿资料进行回顾性分析。结果:46.15%的患儿高胆红素血症发生的时间为0.25(6h)～3天,53.85%的患儿高胆红素血症发生时间为4～7天。169例高胆红素血症的发生因素依次为:感染因素(59.17%),ABO溶血(19.53%),围产因素(15.98%)和其他因素(5.32%)。治疗主要采取蓝光照射,同时消除导致胆红素升高的因素。169例高胆红素血症患儿无一例发生胆红素脑病,无一例死亡。结论:导致足月新生儿高胆红素血症的首要因素为感染,其次是ABO溶血、围产因素等。蓝光照射是安全快速降低血清胆红素水平的首选方法。
Objective: To study the factors, treatment and prognosis of full-term neonatal hyperbilirubinemia. Methods: The data of 169 cases of full-term neonates with hyperbilirubinemia admitted to our hospital from April 2004 to May 2007 were analyzed retrospectively. Results: 46.15% of children with hyperbilirubinemia occurred in 0.25 (6h) ~ 3 days, 53.85% of children with hyperbilirubinemia occurred in 4 to 7 days. The incidence of 169 cases of hyperbilirubinemia were: infection (59.17%), ABO hemolysis (19.53%), perinatal factors (15.98%) and other factors (5.32%). Treatment mainly blue light irradiation, while eliminating the factors that lead to elevated bilirubin. None of the 169 children with hyperbilirubinemia developed bilirubin encephalopathy and none died. CONCLUSIONS: The primary contributor to hyperbilirubinemia in term neonates was infection, followed by ABO hemolysis and perinatal factors. Blue light exposure is the safest and fastest way to lower serum bilirubin levels.