论文部分内容阅读
目的:探讨羟糖甘滴眼液在高原地区干眼症患者中应用的临床疗效及安全性。方法:采用前瞻性研究,观察高原地区干眼患者185例(370眼),随机分为观察组与对照组。观察组(93例)使用羟糖甘滴眼液,每日4次,对照组(92例)采用玻璃酸钠滴眼液,每日4次,观察指标包括:用药前,用药8周后干眼症状、泪膜破裂试验(BUT)、Schirmer I试验,比较两组的差异。结果:用药8周后,观察组显效率为39.78%,而对照组为17.39%,观察组优于对照组,差异有统计学意义(P<0.05);好转率治疗组为49.46%,对照组为43.48,两组比较差异有统计学意义(P<0.01)。结论:羟糖甘与玻璃酸钠滴眼液对干眼患者自觉症状、体征均有改善,无不良反应,但羟糖甘滴眼液临床疗效明显优于后者,可作为高原地区干眼症患者一线使用药物。
Objective: To investigate the clinical efficacy and safety of Xoguangan eye drops in the treatment of dry eye patients in the plateau area. Methods: A prospective study was conducted to observe 185 patients (370 eyes) with dry eye in the plateau area and randomly divided into observation group and control group. The observation group (93 cases) used the sugar alcohol eye drops 4 times a day, while the control group (92 patients) used sodium hyaluronate eye drops 4 times a day. The observed indexes include: medication before treatment, dry eye symptoms after 8 weeks , Tear film rupture test (BUT), Schirmer I test, the differences between the two groups were compared. Results: After 8 weeks of treatment, the effective rate of the observation group was 39.78%, while the control group was 17.39%, the observation group was superior to the control group, the difference was statistically significant (P <0.05); the improvement rate of the treatment group was 49.46% Was 43.48, the difference between the two groups was statistically significant (P <0.01). CONCLUSION: Hydroxyvitamin and sodium hyaluronate eye drops have better symptoms and signs in patients with dry eye without any adverse reactions, but the clinical effect is better than the latter, which can be used as dry eye in plateau area Patients first-line use of drugs.