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以前我们曾研究3,5-二硝基-4-氯三氟甲苯(1a)和3,5-二硝基-2-氯三氯甲苯(1b)与含硫亲核试剂的反应,D’Amico等最近报道了1,1-二巯基-2,2-二氰乙烯的钾盐与1的反应,因为1中的苯环母体上有三个强吸电子基因,容易与多种亲核试剂反应,早期曾有人研究过3,5-二硝基-4-氯吡啶与取代的邻苯二胺的反应,本文报道1与一些含氮有机亲核试剂的反应,合成了新的含氟杂环化合物2和3。
We have previously studied the reaction of 3,5-dinitro-4-chlorobenzotrifluoride (1a) and 3,5-dinitro-2-chlorotrichlorotoluene (1b) with sulfur-containing nucleophiles, D ’ Recently, Amico et al. Reported the reaction of potassium salt of 1,1-dimercapto-2,2-dicyanoethylene with 1 because there are three strong electron-withdrawing genes on the benzene ring precursor in 1 and are easily reacted with various nucleophiles , The reaction of 3,5-dinitro-4-chloropyridine with substituted ortho-phenylenediamine has been studied in the early stage. We report here the reaction of 1 with some nitrogen-containing organic nucleophiles and the synthesis of new fluorine-containing heterocycles Compounds 2 and 3.