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清除树脂是一种特殊的固相试剂。近五年 ,它们被广泛的用于平行液相法合成组合化学库 ,简化液相组合化学库的纯化操作。本文综述了清除树脂在纯化操作中的使用策略。根据清除纯化原理 ,介绍了共价键型和离子键型两类清除树脂。给出了清除树脂在组合化学中的具体应用实例。最后对清除树脂的发展作了展望。
Clear resin is a special solid phase reagent. In the recent five years, they have been widely used in the parallel liquid phase synthesis of combinatorial chemical libraries, simplifying the purification of liquid phase combinatorial chemical libraries. This article reviews the strategies used to purify resins in purification operations. According to the principle of purifying and purifying, introduced two kinds of covalent and ion-type resin. A practical example of removing resins in combinatorial chemistry is given. Finally, the development of resin removal is prospected.