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Allylalkoxydimethylsilanes (2) condense with (-)-menthyl glyoxylate (3) in the presence of Lewis acid to give optically active menthyl 2-hydroxy-4-pentenoate (7) with optical purity of 31-42%. Factors affecting the yield and de of 7 have been examined. The stereochemistry of transition state of the reaction was discussed.
(2) condense with (-) - menthyl glyoxylate (3) in the presence of Lewis acid to give optically active menthyl 2-hydroxy-4-pentenoate (7) with optical purity of 31-42%. Factors affecting the yield and de of 7 have been examined. The stereochemistry of transition state of the reaction was discussed.