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我们通过测定反映血浆儿茶酚胺水平的去甲肾上腺素(PNA)、肾上腺素(PA)及尿前列腺素 E_2(PGE_2)、6-酮-前列腺素 F_(1α)(6-K-PGF_(1α))、前列素 F_(2α)(PGF_(2α))、血栓素 B_2(TXB_2)来探讨其在肝硬化患者肾血流动力学改变及 HRS 发生中的作用,为治疗提供理论依据。材料和方法一、病例选择63例均为 HBsAg 阳性的经肝活检诊断的肝硬化住院患者,无消化道出血及肾、心疾病。进入研究前未服非甾类抗炎药(NSAID)。根据临床表现及肝肾功能减损情况分为代偿纽(CC)19例,男14例,女5例,平均年龄42.5岁;失代偿组(DC)26例,男22例,女4例,平均年龄46.1岁;HRS 组18例,男13例,女5例,平均年龄42岁。正常对照组(NC)20例,为健康献血员及医务人员,无肝、心、肾疾病,其中男15例,女5例,平均年龄36.1岁。
We measured the plasma levels of norepinephrine (PNA), adrenaline (PA) and urinary prostaglandin E_2 (PGE_2) and 6-Keto-prostaglandin F 1α (6-K-PGF_ (1α) (2α), thromboxane B_2 (TXB_2) in patients with cirrhosis, and to explore its role in the changes of renal hemodynamics and the occurrence of HRS in cirrhotic patients, so as to provide a theoretical basis for the treatment. Materials and methods A case selection 63 cases were HBsAg positive liver biopsy diagnosed cirrhosis hospitalized patients without gastrointestinal bleeding and kidney and heart disease. Before entering the study did not take non-steroidal anti-inflammatory drugs (NSAIDs). According to the clinical manifestations and the impairment of liver and kidney function, there were 19 cases of decompensated Newcastle disease (CC), 14 males and 5 females, with an average age of 42.5 years; 26 cases of decompensation (DC), 22 males and 4 females , The average age of 46.1 years; 18 cases of HRS group, 13 males and 5 females, mean age 42 years. Normal control group (NC) 20 cases, healthy blood donors and medical staff, no liver, heart and kidney disease, including 15 males and 5 females, with an average age of 36.1 years old.