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原发性胆囊癌是胆道系统最常见的恶性肿瘤,手术是目前公认的最有效的治疗方法。但因其恶性程度高,又缺乏特异性的临床表现,早期诊断困难,多数患者就诊时已属中晚期,伴发肝脏浸润或远处转移,失去了根治切除的机会,生存率低,预后差。近年来随着分子生物学技术的迅速发展,已从分子水平逐步阐明了肿瘤的发生、发展机制,也为肿瘤的治疗提供了一条新途径。特别在关于肿瘤新生血管调控及抗血管治疗等方面的研究,已取得了重要成果。
Primary gallbladder cancer is the most common malignant tumor of the biliary tract, and surgery is the most accepted treatment. However, due to its high degree of malignancy, but also the lack of specific clinical manifestations, early diagnosis difficult, most patients are already in the treatment of advanced stage, associated with liver infiltration or distant metastasis, lost the chance of radical resection, low survival rate, poor prognosis . In recent years, with the rapid development of molecular biology technology, it has clarified the occurrence and development mechanism of tumors from the molecular level and provided a new way for the treatment of tumors. In particular, research on tumor angiogenesis and antiangiogenic therapy has yielded important results.