论文部分内容阅读
1990～1994年,我们收治EB病毒(EBV)感染新生儿48例,现报告如下。 临床资料:本组发病日龄8～28天,平均16.4天。足月儿44例,早产儿4例。主要临床表现为发热,少数有黄疸;脐部化脓伴肺炎14例,肠炎8例,心肌炎5例,脑膜炎3例;合并败血症32例,其中血培养为表皮葡萄球菌21例,金黄色葡萄球菌9例,枯草杆菌及类白喉杆菌各1例。EBV-IgM酶标检查均阳性。 治疗及疗效:将48例随机分为两组治疗,一组单用抗生素22例,二组用抗生素加双黄连26例。抗生素均采用氨苄青霉素及先锋霉素V常规剂量联合用药;双黄连为静脉用粉针剂,用量为60mg/(kg·d)。结果:抗生素组11～38天治愈,平均15.86天;抗生素加双黄连组6～22天治愈,平均10.62天,两组有显著差异(P<0.05)。
From 1990 to 1994, we received EB virus (EBV) infection in 48 newborns, are as follows. Clinical data: The onset of this group of 8 to 28 days, an average of 16.4 days. 44 full-term children, 4 premature children. The main clinical manifestations of fever, a few jaundice; umbilical festering with pneumonia in 14 cases, 8 cases of enteritis, myocarditis in 5 cases, meningitis in 3 cases; combined sepsis in 32 cases, of which blood culture Staphylococcus epidermidis 21 cases, Staphylococcus aureus 9 cases, Bacillus subtilis and diphtheria-like bacteria in 1 case. EBV-IgM enzyme test were positive. Treatment and efficacy: 48 cases were randomly divided into two groups, one group of 22 cases of antibiotics alone, two groups with antibiotics plus Shuanghuanglian 26 cases. Antibiotics are ampicillin and cephalosporin V conventional dose combination; Shuanghuanglian intravenous injection, the dosage of 60mg / (kg · d). Results: The antibiotic group was cured for 11 to 38 days with an average of 15.86 days. The antibiotic plus Shuanghuanglian group was cured within 6 to 22 days with an average of 10.62 days (P <0.05).