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多年来的研究表明 ,6号染色体长臂的杂合性缺失 ( L OH)是人类肿瘤中最常见的染色体改变之一 ,人们认为在区域上可能存在有一个或几个肿瘤抑制基因 ,并且它 (们 )的缺失或失活在肿瘤的发生发展过程中起重要作用
Studies over the years have shown that the loss of heterozygosity (L OH) on the long arm of chromosome 6 is one of the most common chromosomal changes in human tumors. It is thought that there may be one or more tumor suppressor genes in the region and it Loss or inactivation of (s) plays an important role in the development of tumors