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研究牛乳蛋白过敏儿童血清中对4种主要乳蛋白过敏原的抗体特异性情况。采用间接酶联免疫吸附法测定乳过敏儿童血清中4种乳蛋白过敏原特异性IgE抗体。结果显示,乳过敏儿童血清中α-乳白蛋白和β-乳球蛋白的特异性IgE比例较高,特异性IgE阳性率分别可达44.3%和39.3%,其次α-酪蛋白和β-酪蛋白特异性IgE阳性率为31.2%和36.1%。研究结果表明,乳过敏儿童对4种乳蛋白过敏原都有一定比例的特异性IgE抗体,其中α-LA和β-LG的阳性率较高,是乳蛋白过敏儿童的主要过敏原蛋白,大部分乳过敏儿童不止对1种乳蛋白过敏。
To investigate the antibody specificity of four major milk protein allergens in milk serum from cow’s milk allergy sufferers. Indirect ELISA was used to determine the four milk protein allergen-specific IgE antibodies in serum of milk-allergic children. The results showed that milk-allergic children serum α-lactalbumin and β-lactoglobulin specific IgE higher specific IgE-positive rates were 44.3% and 39.3%, followed by α-casein and β-casein The positive rates of specific IgE were 31.2% and 36.1%. The results show that milk allergy children have a certain proportion of the four kinds of milk protein allergens specific IgE antibodies, which α-LA and β-LG positive rate is high, milk protein allergy children’s major allergen protein, large Some milk allergy children not only to a milk protein allergy.