本文对４４例肺癌术前患者血清免疫抑制酸性蛋白（ＩＡＰ）含量及外周血Ｔ淋巴细胞亚群进行了检测，与正常组比较。结果表明：肺癌患者血清ＩＡＰ含量显著增高（Ｐ＜００１），Ｔ亚群ＣＤ３＋，ＣＤ４＋细胞均显著降低（Ｐ＜００１），ＣＤ８＋细胞显著增高（Ｐ＜００５），ＣＤ４＋／ＣＤ８＋细胞比值亦显著降低（Ｐ＜００１）；并发现患者血清ＩＡＰ含量的增高与其外周血Ｔ细胞亚群ＣＤ４＋／ＣＤ８＋细胞比值的降低呈明显负相关（ｒ＝０４２；Ｐ＜００１）。在患者中有肺外转移者血清ＩＡＰ含量明显高于未转移者（Ｐ＜００１）；其Ｔ细胞ＣＤ４＋／ＣＤ８＋比值亦明显低于未转移者（Ｐ＜００１）。提出联合检测对患者免疫水平评估和预后的判断更具有一定的意义。 In this paper, the serum immunosuppressive acidic protein (IAP) levels and peripheral blood T-lymphocyte subsets were measured in 44 patients with lung cancer before surgery, compared with the normal group. The results showed that serum IAP levels in lung cancer patients were significantly higher (P<001), T cell subsets CD3+, CD4+ cells were significantly lower (P<001), CD8+ cells were significantly higher (P<005), CD4+/ The ratio of CD8+ cells was also significantly decreased (P<001). It was found that the increase in serum IAP levels was negatively correlated with the decrease in the ratio of CD4+/CD8+ cells in peripheral blood T-cell subsets (r=-42; P< 001). In patients with extrapulmonary metastases, serum IAP levels were significantly higher than those without metastases (P<001); their T cell CD4+/CD8+ ratios were also significantly lower than those without metastases (P<001). The proposed joint detection has a certain significance in the evaluation of the patient’s immune level and the prognosis of the prognosis.