口服甾体激素避孕药已有20余年历史,国内外现已广泛应用。但口服避孕药对服药妇女本人及其后代能否造成远期、潜在性危害?已引起科学工作者的重视,并开展了各方面的研究。有些学者,如Mcquarrie 和Littlefield等认为口服甾体激素避孕药,可以引起人体外周血液淋巴细胞染色体畸变率增加。但也有另一些学者,如Feit 等认为口服甾体激素避孕药,不影响染色体的断裂和畸变。结论并不一致。为了进一步了解口服甾体激素避孕药的遗传学效应,本文作了初步的探讨。 Oral steroid hormonal contraception has been more than 20 years of history, is now widely used at home and abroad. However, whether oral contraceptives cause long-term and potential harm to the women themselves and their descendants has drawn great attention of scientists and has carried out various researches. Some scholars, such as Mcquarrie and Littlefield think oral steroid hormones contraceptives, can cause peripheral blood lymphocyte chromosome aberration rate increased. But there are other scholars, such as Feit and other oral steroid hormones that do not affect the chromosome breakage and distortion. The conclusion is not consistent. In order to further understand the genetic effects of oral steroid hormone contraceptives, this paper made a preliminary discussion.