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The authors sequenced the entire mitochondrial DNA coding region in a group of 19 patients with non arteritic anterior ischemic optic neuropathy (NAION) and in 100 controls. Synonymous and nonsynonymous nucleotide changes were more commo n in NAION patients (p <.0.001). Twelve of these (11 novel) were potentially pat hologic, nine of which altered moderately or highly conserved amino acids in the functional domain of the affected protein. Mitochondrial malfunction may be a r isk factor for NAION.
The authors sequenced the entire mitochondrial DNA coding region in a group of 19 patients with non arteritic anterior ischemic optic neuropathy (NAION) and in 100 controls. Synonymous and nonsynonymous nucleotide changes were more commn n in NAION patients (p <.0.001). Twelve of these (11 novel) were potentially pat hologic, nine of which altered moderately or highly conserved amino acids in the functional domain of the affected protein. Mitochondrial malfunction may be ar isk factor for NAION.