脑恶性肿瘤的特点是浸润性生长。96％的脑恶性胶质瘤为单发,极少发生颅内-外转移,且90％以上是原位复发。而大多数化疗药难于透过血脑屏障。为提高肿瘤部位化疗药浓度以增加疗效,并减少全身副作用,我科自1984年10月至1986年10月在15例脑恶性肿瘤的16次手术中使用了局部化疗(表1) Malignant brain tumors are characterized by invasive growth. Ninety-six percent of brain glioblastomas are solitary, with minimal intracranial-lateral metastases, and more than 90% are in situ. Most chemotherapy drugs are difficult to cross the blood-brain barrier. To increase the concentration of chemotherapeutic agents at the tumor site to increase efficacy and reduce systemic side effects, local chemotherapy was used in 16 surgeries of 15 patients with malignant brain tumors from October 1984 to October 1986 (Table 1)