Objective: Even if the majority of patients with Guillain-Barrésyndrome (GBS) have a favourable functional outcome some residual motor and sensory signs and symptoms may remain. The aim of this study was to evaluate the long-term effect of GBS on daily life, working activities, hobbies and social status and the presence of residual symptoms. Patients and methods: Seventy patients with GBS enrolled in a case-control study were examined. Information on signs or symptoms during the acute phase of the disease was retrieved from medical records and an ad-hoc questionnaire administered during hospitalization. Patients were interviewed by phone 3 to 5 years after disease onset about residual symptoms and changes in daily living. Disability and handicap were assessed using the Hughes, Rankin and Rotterdam 9-items scale. Results: At follow-up 45 patients (64%) made a complete functional recovery; 19 patients (27%) had some minor limitations in daily life although they were able to perform all their activities independently while 6 (9%) needed aid for some hours or continuously during the day. Ninetee n patients (27%) had, however, to make substantial changes in their job, hobbie s or social activities. There was no significant correlation between clinical an d laboratory features during the acute phase of GBS and outcome. Conclusions: Al thoough over 90 %of our GBS patients had a more or less complete functional rec overy, almost 30 %of them had to make substantial changes in daily life. These findings indicate that GBS still has a significant impact on patients’life which may go beyond their residual disability or impairment. Treatment of GBS should not be only aimed at improving patients’disability but also at limiting the im pact of the disease on their social life. Objective: Even if the majority of patients with Guillain-Barrésyndrome (GBS) have a favourable functional outcome some residual motor and sensory signs and symptoms may remain. The aim of this study was to evaluate the long-term effect of GBS on daily life, Working activities, hobbies and social status and the presence of residual symptoms. Patients and methods: Seventy patients with GBS enrolled in a case-control study were examined. Information on signs or symptoms during the acute phase of the disease was retrieved from medical records and an ad-hoc questionnaire administered during hospitalization. Patients were interviewed by phone 3 to 5 years after disease onset about residual symptoms and changes in daily living. Disability and handicap were assessed using the Hughes, Rankin and Rotterdam 9-items scale. Results: At follow-up 45 patients (64%) made a complete functional recovery; 19 patients (27%) had some minor limitations in daily life although they were able to perform all Ninetee n patients (27%) had, however, to make substantial changes in their job, hobbie s or social activities. There was no significant correlation Between clinical an d laboratory features during the acute phase of GBS and outcome. Conclusions: Al thoough over 90% of our GBS patients had a more or less complete functional rec overy, almost 30% of them had to make substantial changes in daily life. These Investigation indicate that GBS still has a significant impact on patients’life which may go beyond their residual disability or impairment. Treatment of GBS should not be only aimed at improving patients’disability but also at limiting the im pact of the disease on their social life.