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目的探讨至灵胶囊联合缬沙坦治疗慢性肾病的疗效及对患者肾功能的影响。方法将76例慢性肾病患者按照随机数字表法分为观察组和对照组,每组38例。对照组采用缬沙坦治疗,观察组在对照组基础上给予至灵胶囊治疗,对比2组治疗效果。于治疗前及治疗后,检测2组患者的T淋巴细胞(CD3、CD4、CD4/CD8)、可溶性细胞黏附因子-1(sICAM-1)及肾功能指标[血肌酐(Scr)、血尿素氮(BUN)、尿白蛋白排泄率(UAER)、肾小球滤过率(GFR)]变化情况。结果观察组治疗效果显著优于对照组,差异有统计学意义(z=2.262,P<0.05)。观察组治疗后CD3显著升高,CD4、CD4/CD8、s ICAM-1显著降低,差异有统计学意义(P<0.05);对照组治疗后sICAM-1显著下降(P<0.05)。治疗后,观察组CD3显著高于对照组,CD4、CD4/CD8、s ICAM-1显著低于对照组,差异有统计学意义(t=6.642、6.734、5.462、2.319,P<0.05)。2组治疗后Scr、BUN、UAER显著降低,GFR显著升高,差异有统计学意义(P<0.05);治疗后,观察组Scr、BUN、UAER显著低于对照组,GFR显著高于对照组,差异有统计学意义(t=4.390、2.386、3.824、2.719,P<0.05)。结论至灵胶囊联合缬沙坦能显著改善慢性肾病患者的免疫功能,提高肾功能。
Objective To investigate the effect of Zhiling capsule combined with valsartan on chronic kidney disease and its effect on renal function. Methods 76 patients with chronic kidney disease were divided into observation group and control group according to random number table method, with 38 cases in each group. The control group was treated with valsartan, the observation group was given Ling capsule on the basis of the control group, and the therapeutic effect was compared between the two groups. T lymphocytes (CD3, CD4, CD4 / CD8), sICAM-1 and renal function indexes [serum creatinine (Scr), blood urea nitrogen (BUN), urinary albumin excretion rate (UAER), glomerular filtration rate (GFR)] changes. Results The observation group was significantly better than the control group, the difference was statistically significant (z = 2.262, P <0.05). The level of CD3, CD4, CD4 / CD8, s ICAM-1 in the observation group was significantly higher than that in the control group (P <0.05). The sICAM-1 in the control group decreased significantly after treatment (P <0.05). After treatment, the level of CD3 in the observation group was significantly higher than that in the control group. The levels of CD4, CD4 / CD8 and s ICAM-1 in the observation group were significantly lower than those in the control group (t = 6.642,6.734,5.462,2.319, P <0.05). After treatment, Scr, BUN and UAER in the two groups were significantly decreased, GFR was significantly increased, the difference was statistically significant (P <0.05); after treatment, the Scr, BUN and UAER in the observation group were significantly lower than those in the control group , The difference was statistically significant (t = 4.390,2.386,3.824,2.719, P <0.05). Conclusion Zhiling capsule combined with valsartan can significantly improve the immune function of patients with chronic kidney disease and improve renal function.