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目的 :研究细胞色素P45 0 2E1(CYP2E1)基因多态性与肝癌易感性的关系。方法 :在肝癌高发区泰兴市进行病例对照研究 ,调查研究对象的饮酒习惯 ,以PCR RFLP方法分析CYP2E1基因型。结果 :肝癌病例组与对照组中CYP2E1变异基因型 (C1/C2 +C2 /C2 )的分布频率分别为 41 0 6%和 3 7 0 2 % ,两者差异无统计学意义 ;从饮酒习惯等方面分析 ,携带CYP2E1变异基因型的饮酒者与携带野生基因型的不饮酒者间患肝癌危险性差异无统计学意义。结论 :CYP2E1基因多态性与泰兴市肝癌的发生无关
Objective: To study the relationship between the genetic polymorphism of cytochrome P45 0 2E1 (CYP2E1) and susceptibility to hepatocellular carcinoma. Methods: A case-control study was conducted in Taixing, a high incidence area of liver cancer. The drinking habit of the subjects was investigated, and the genotypes of CYP2E1 were analyzed by PCR RFLP. Results: The frequencies of CYP2E1 variant genotypes (C1 / C2 + C2 / C2) were 41 0 6% and 37 0 2% respectively in hepatocellular carcinoma cases and controls, with no significant difference between the two groups. In terms of analysis, there was no significant difference in the risk of liver cancer between drinkers carrying CYP2E1 genotype and non-drinkers carrying wild genotypes. Conclusion: CYP2E1 gene polymorphism has nothing to do with the occurrence of liver cancer in Taixing