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用细菌培养和菌落计数的方法对大鼠肝衰竭模型的胃肠道、胆道及肠系膜淋巴结内的细菌进行了检测；另对４例肝衰患者胃液进行细菌培养。结果显示，实验组大鼠消化道内细菌大量上移，胃、空肠、回肠内细菌含量分别为４．７×１０４／ｍｌ、２．１×１０５／ｍｌ、５．５×１０６／ｍｌ；对照组分别为４．６×１０２／ｍｌ、６．１×１０１／ｍｌ、２．４×１０３／ｍｌ，差异有显著性意义。实验组大鼠胆道及肠系膜淋巴结内均可培养到细菌。患者胃液中亦有大量细菌存在。病理学观察发现，肝衰竭大鼠胃肠胀气明显，肠壁松弛，管腔扩张；局部粘膜糜烂、出血；近端小肠粘膜病变最为明显。结论：肝衰竭时可以出现肠道菌群上移，引起胃肠胀气、内毒素吸收增加、细菌易位、消化道出血、自发性腹膜炎等。这种肠道菌群引起的内源性感染是肝衰竭最终导致多器官功能衰竭的始动原因。
The bacteria in the gastrointestinal tract, biliary tract and mesenteric lymph nodes in rat model of liver failure were detected by bacterial culture and colony counting. The gastric juice was also cultured in 4 patients with liver failure. The results showed that the bacteria in the digestive tract of rats in the experimental group moved up a lot, the contents of bacteria in stomach, jejunum and ileum were 4.7 × 104 / ml, 2.1 × 105 / ml and 5.5 × 106 / ml, respectively. Respectively 4.6 × 102 / ml, 6.1 × 101 / ml, 2.4 × 103 / ml, the difference was significant. Bacteria could be cultured in the biliary tract and mesenteric lymph nodes in the experimental group. There are also a large number of bacteria in gastric juice. Pathological observation found that liver failure rats with flatulent flatulence, intestinal wall relaxation, lumen expansion; local mucosal erosion, bleeding; proximal intestinal mucosal lesions most obvious. Conclusion: Liver failure can occur when the intestinal flora moves upwards, causing flatulence, increased endotoxin absorption, bacterial translocation, gastrointestinal bleeding and spontaneous peritonitis. This intestinal flora-induced endogenous infection is the initiating cause of liver failure eventually leading to multiple organ failure.