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[目的]分析心理干预对哮喘患者心理、生存质量及Th1/Th2平衡的影响。[方法]将106例哮喘患者随机分为实验组和对照组,在常规药物治疗的基础上,实验组同时接受心理干预。采用激惹、抑郁和焦虑自评量表(IDA)及支气管哮喘生存质量评估表(AQLQ)分别比较两组治疗前后的心理状态、生存质量及血清中白细胞介素12、13(IL-12、13)含量的变化。[结果]治疗后实验组的抑郁、焦虑、外向性激惹评分均低于对照组(P﹤0.01);治疗后实验组的活动受限、哮喘症状、心理状况3个因子的得分均高于对照组(P﹤0.01);治疗后实验组IL-12含量升高及IL-13降低较对照组明显,差异有统计学意义(P﹤0.05)。[结论]心理干预能改善哮喘患者心理状态、提高其生存质量,且能上调IL-12,下调IL-13,调节Th1/Th2免疫失衡,从而达到控制哮喘的目的。
[Objective] To analyze the effect of psychological intervention on psychological, quality of life and Th1 / Th2 balance in patients with asthma. [Methods] 106 patients with asthma were randomly divided into experimental group and control group. On the basis of routine drug treatment, the experimental group received psychological intervention at the same time. The psychological status, quality of life and serum levels of IL-12, IL-12, IL-12 and IL-12 in the two groups were compared before and after treatment by using IDA and AQLQ, 13) Changes in content. [Results] After treatment, the scores of depression, anxiety and extroversion in experimental group were lower than those in control group (P <0.01). After treatment, the activity of experimental group was limited. The scores of asthma symptoms and psychological status were all higher than those of experimental group (P <0.01). After treatment, the levels of IL-12 and IL-13 in the experimental group were significantly lower than those in the control group (P <0.05). [Conclusion] Psychological intervention can improve the psychological status of asthma patients, improve their quality of life, and can up-regulate IL-12, down-regulate IL-13 and regulate Th1 / Th2 immune imbalance so as to achieve the aim of controlling asthma.