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作者分析了近来3个抗高血压治疗试验结果, 共包括老年轻中度原发性高血压10759例。老年收缩期高血压研究:共4736例,单纯收缩期高血压[收缩压160～214mmHg(21.3～28.5kPa,1kPa=7.5mmHg),舒张压<90mmHg],年龄60岁。开始治疗口服氯噻酮每日12.5至25mg,据需要加服阿替洛尔每日25mg或安慰剂。平均随访4.5年,收缩压下降11.1mmHg,舒张压下降3.4mmHg,卒中减少36％(P=0.0004),冠心病减少28％(P=0.01),血管性死亡减少23％(P=0.05)。瑞典老年高血压试验:共1627例,血压180～230/105～120mmHg,年龄70至84岁。随机口服阿
The authors analyzed the results of three recent antihypertensive treatment trials, including a total of 10,759 elderly patients with mild to moderate essential hypertension. Elderly systolic hypertension study: a total of 4736 cases of isolated systolic hypertension [systolic blood pressure 160 ~ 214mmHg (21.3 ~ 28.5kPa, 1kPa = 7.5mmHg), diastolic blood pressure <90mmHg], age 60 years. Start treatment of oral chlorthalidone 12.5 to 25mg daily, according to the need to add atenolol 25mg daily or placebo. Mean follow-up was 4.5 years. The systolic blood pressure decreased by 11.1mmHg, diastolic blood pressure decreased by 3.4mmHg, stroke decreased by 36% (P = 0.0004), coronary heart disease decreased by 28% (P = 0.01) and vascular death decreased by 23% (P = 0.05). Sweden elderly hypertension test: a total of 1627 cases, blood pressure 180 ~ 230/105 ~ 120mmHg, aged 70 to 84 years old. A random oral