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肽能以完整分子的形式通过血脑屏障(BBB),影响中枢神经系统(CNS)的功能。肽是以饱和与不饱和的机制从脑—血或血—脑方向通过BBB的。药剂和生理变化可影响肽的转运通道,特别是饱和转运通道。这表明肽及其类似物能治疗CNS疾病,并提示了一些增加疗效的方法,如控制转运率,治疗由于BBB与肽相互作用改变而产生的靶疾病,以及研制能利用细胞旁透膜扩散和脑—血转运通道机制的肽类似物。
Peptides can pass through the blood-brain barrier (BBB) as intact molecules that affect the function of the central nervous system (CNS). Peptides cross the BBB in a brain-blood or blood-brain direction with both saturated and unsaturated mechanisms. Pharmacological and physiological changes can affect peptide transport channels, especially saturated transport channels. This suggests that peptides and their analogs are capable of treating CNS disease and suggest ways to increase efficacy, such as control of transit rates, treatment of target diseases resulting from changes in the interaction of BBB with peptides, and development of strategies that exploit cell-permeable membrane diffusion and Peptide analogues of the brain-blood transport pathway.