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核磁共振成像技术已成功的应用于肿瘤的临床诊断。此技术的发展促进了新药剂的研究。而新药剂使病变组织与正常组织的图像产生足够的反差。由水的质子核磁共振信号构成的~1HNMR图像强度依赖于氢核的弛豫时间。顺磁性过渡金属和稀土离子配合物通过偶极相互作用缩短其核附近质子的弛豫时间。作为核磁共振成像反差增进剂,稀土氮杂大环多羧酸配合物很有应用前景。本文合成了新的氮杂大环多羧酸稀土配合物[La(NOTMA)(H_2O)_8]·4H_2O,测定了其晶体结构。
Magnetic resonance imaging has been successfully applied to the clinical diagnosis of tumors. The development of this technology has promoted the research of new medicaments. The new agent to the lesion tissue and normal tissue images produce sufficient contrast. The intensity of ~ 1H NMR images composed of proton NMR signals of water depends on the relaxation time of the hydrogen nuclei. The paramagnetic transition metal and rare earth ion complexes shorten the relaxation time of protons near their nuclei by dipole interaction. As a contrast enhancer for NMR imaging, rare earth aza macrocyclic polycarboxylic acid complexes are promising. In this paper, a new rare earth complex [La (NOTMA) (H_2O) _8] · 4H_2O was synthesized and its crystal structure was determined.