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作者对2202例急性白血病(AL)诊断后存活5年或更长的病例作了回顾性分析,以弄清长期随访能否为设计更有效的化疗方案提供一种有效的手段及缓解后化疗停用的时机.病例来自日本300个医学研究所,从60年代至80年代可资分析的2202例AL中,儿童1607例(ALL 1380例,ANLL 196例,未能分型33例)成人595例(ALL 122例,ANLL471例,未能分型2例).1974年前,大部分儿童ALL使用化疗持续5年或更长.此后渐改为3-5年,至80年代45.6%病人化疗3-5年.成人AN-LL在1970-1974年64%化疗为5年或以上,而到
The authors retrospectively analyzed 2202 cases of acute leukemia (AL) who had survived for 5 years or longer in order to determine whether long-term follow-up could provide an effective means for designing more effective chemotherapy regimens and to relieve postchemotherapy. The timing of the study. The cases were from 300 medical institutes in Japan. There were 2202 AL cases available for analysis from the 1960s to the 1980s. There were 1607 children (ALL 1380 cases, 196 ANLL cases, 33 untyped cases) and 595 adult cases. (ALL 122 patients, ANLL 471 patients, and 2 patients failed to be classified). Before 1974, most children with ALL continued to use chemotherapy for 5 years or more. Later, they changed to 3-5 years, and 45.6% of patients received chemotherapy in the 1980s3. -5 years. Adult AN-LL treated with 64% chemotherapy for 5 years or more in 1970-1974