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为了比较急性单核细胞白血病M_(5a)和M_(5b)细胞遗传学差异,并研究其与临床行为之间的相互关系,采用骨髓直接法和24小时短期培养法制备染色体标本,用G显带技术对58例成人初发急性单核白血病细胞进行核型分析,同时对其临床资料进行回顾性研究。结果表明58例患者中正常核型28例,异常核型30例,其中正常核型在M5b中出现率高于M5a(P=0.0001),异常核型中11q23异常和+8染色体在M5a中均较M5b常见(P<0.01);临床上异常核型的M5患者常有高白细胞(WBC)计数,中枢神经系统浸润,完全缓解(CR)率低及存活期明显缩短的特征。结论急性单核细胞白血病在遗传和临床上是一组异质性疾病,但M5a和M5b似乎具有各自独特的遗传学背景和临床表现。
In order to compare the cytogenetic differences of M_ (5a) and M_ (5b) in acute monocytic leukemia and to study the relationship between M_ (5a) and M_ (5b) cytogenetics, the chromosomal specimens were prepared by direct method of bone marrow and short- With technical analysis of 58 cases of adult patients with acute monocytic leukemia cells karyotype analysis, and its clinical data were retrospectively studied. The results showed that there were 28 cases of normal karyotype and 30 cases of abnormal karyotype in 58 cases. The normal karyotype was higher in M5b than in M5a (P = 0.0001), 11q23 in abnormal karyotype and +8 in M5a (P <0.01). M5 patients with clinically abnormal karyotype often have high white blood cell (WBC) counts, central nervous system infiltration, complete remission (CR) rate and shortened survival. Conclusion Acute monocytic leukemia is a heterogeneous group of diseases, both genetically and clinically, but M5a and M5b appear to have unique genetic backgrounds and clinical manifestations.