给药方案设计,首先通过用药后,经不同时间取血样测得血药浓度数据,经药代动力学原理进行数据的处理求算出动力学参数,比如,消除速率常数 K 和分布容积 V;同时明确了安全有效的血药浓度范围后,在此基础上,确定剂量 X_。和给药间隔τ,经多次给药即可达到期望的有效血药浓度。但临 Dosing regimen design, first through the use of drugs, blood samples taken at different times measured blood drug concentration data, the pharmacokinetic principles of data processing calculated kinetic parameters, such as the elimination of the rate constant K and distribution volume V; at the same time Clear a safe and effective blood concentration range, on this basis, to determine the dose X_. And administration interval τ, after repeated administration to achieve the desired effective plasma concentration. But Pro