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目的:观察纳洛酮与氨茶碱联合治疗早产儿呼吸暂停的临床效果。方法:22例患儿随机分为两组,治疗组12例在应用纳洛酮的基础上加用氨茶碱,对照组10例单用氨茶碱,两组各用3～5天,观察两组的临床效果。结果:纳洛酮与氨茶碱治疗组显效7例,显效率58%(7/12);有效4例,有效率33%(4/12);总有效率92%(11/12)。氨茶碱对照组显效4例,显效率40%(4/10);有效3例,有效率30%(3/10);总有效率70%(7/10)。两组比较差异有统计学意义(P<0.01)。结论:氨茶碱和纳洛酮联合应用治疗早产儿呼吸暂停比单用氨茶碱效果好,值得临床推广。
Objective: To observe the clinical effect of naloxone combined with aminophylline in the treatment of apnea in premature infants. Methods: Twenty-two children were randomly divided into two groups. In the treatment group, aminophylline was used in 12 patients on the basis of naloxone, and aminophylline in 10 patients in the control group for 3 to 5 days. The clinical effect of two groups. Results: Naloxone and aminophylline were effective in 7 cases. The effective rate was 58% (7/12). In 4 cases, the effective rate was 33% (4/12). The total effective rate was 92% (11/12). The aminophylline control group was markedly effective in 4 cases, markedly effective rate was 40% (4/10); effective in 3 cases, the effective rate was 30% (3/10); the total effective rate was 70% (7/10). The difference between the two groups was statistically significant (P <0.01). Conclusion: The combination of aminophylline and naloxone in treatment of apnea in preterm infants is better than aminophylline, which is worthy of clinical promotion.