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人们早已发现,下丘脑控制摄食行为。近年来的研究结果表明,存在于中枢神经系统,特别是下丘脑的一些单胺和神经肽类,参与摄食活动的调节,内源性阿片样物质(e(?)dogenous opiate like substance),亦称内啡素(endorphins)便是其中的一种。一、脑内注射吗啡或内啡素可增加摄食β-内啡肽被发现不久,有人发现将它注入大鼠下丘脑的腹内侧核引起摄食增加,并持续1.5小时以上。后来,Tepperman等和Reid等又证明,向该部位注射吗啡(2.7～10.6nMol)也有同样的效应,注射后3小时最明显。Morley等向大鼠侧脑室内注射强啡肽(1～10μg),间隔20分钟后摄食增加;人工合成的脑啡肽类似物——2-丙氨酸甲硫脑啡肽(dalamet)亦有这种作用。在上述实验中,预先或同时中枢或外周给予纳洛酮,则可减弱
It has long been found that the hypothalamus controls feeding behavior. Recent studies have shown that some monoamine and neuropeptides present in the central nervous system, especially the hypothalamus, are involved in the regulation of ingestion activity, ectopic opioids (e) Endorphins are one of them. First, intracerebral injection of morphine or endorphin can increase the intake of β-endorphin was found soon, it was found to inject it into the ventromedial hypothalamic nucleus caused by feeding increased, and continued for 1.5 hours. Later, Tepperman et al. And Reid et al. Demonstrated that injection of morphine (2.7-10.6 nMol) at this site had the same effect, most notably 3 hours after injection. Morley, et al. Intragastric injection of dynorphin (1 ~ 10μg) into the ventricle of rats, with an increase of food intake after 20 minutes. Synthetic enkephalin analogues, 2-alanine dalamet, This effect. In the above experiment, naloxone may be attenuated either beforehand or simultaneously at the center or peripheral