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目的探讨地屈孕酮治疗先兆流产的临床疗效。方法 110例黄体功能不全型先兆流产患者随机分为观察组和对照组,各55例。观察组口服地屈孕酮,对照组肌内注射黄体酮,比较两组患者的治疗效果。结果观察组患者的保胎成功率为90.91%,对照组为89.09%,组间比较差异无统计学意义(P>0.05);用药后,两组的血清孕酮水平均较用药前明显升高(P<0.05),但组间比较差异无统计学意义(P>0.05)。观察组的不良反应发生率略低于对照组,但差异无统计学意义(P>0.05)。结论口服地屈孕酮治疗先兆流产可获得与肌内注射黄体酮相当的临床疗效,且地屈孕酮用药更方便,不良反应小,具有重要的临床应用价值。
Objective To investigate the clinical efficacy of dydrogesterone in the treatment of threatened abortion. Methods 110 cases of luteal insufficiency type threatened abortion were randomly divided into observation group and control group, each 55 cases. Observation group oral droperidone, the control group intramuscular injection of progesterone, the treatment effect of two groups were compared. Results The success rate of miscarriage in the observation group was 90.91% and in the control group was 89.09%, there was no significant difference between the two groups (P> 0.05). After treatment, serum progesterone levels in both groups were significantly higher than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the observation group was slightly lower than that in the control group, but the difference was not statistically significant (P> 0.05). Conclusion Oral dydrogesterone treatment of threatened abortion can be obtained with intramuscular injection of progesterone considerable clinical efficacy, and the dipsterone medication more convenient, less adverse reactions, has important clinical value.