宫颈癌是女性最常见的恶性肿瘤之一。目前认为，宫颈癌表现为从宫颈上皮内病变到侵袭性癌过渡的连续过程。流行病学证据表明单核苷酸多态性(single nucleotide polymorphism，SNP)是定位人类癌症等复杂疾病的重要遗传标志，因此对某些与宫颈癌相关的SNP的研究将有助于宫颈癌的早期诊断和治疗。WNT-1诱导信号通路蛋白1(WNT-1 inducible signaling pathway protein 1，n WISP1)基因多态性与多种肿瘤疾病的易感性密切相关。因此n WISP1基因的单核苷酸多态性可能是影响个体癌症易感性的常见遗传因素。截止目前，仅有少量研究调查n WISP1基因与宫颈癌的关系。因此，本文就n WISP1基因与宫颈癌的研究进展作一综述。n “,”Cervical cancer is currently one of the most common malignant tumors in women.At present, it is considered that cervical cancer shows a continuous process of transition from cervical intraepithelial lesions to invasive cancer.Epidemiological evidence indicates that single nucleotide polymorphism (SNP) is an important genetic marker for the localization of complex diseases such as human cancer.Therefore, research on some SNPs related to cervical cancer will contribute to the early diagnosis and treatment of cervical cancer.The WNT-1 induced signaling pathway protein 1(n WISP1) gene polymorphism is closely related to the susceptibility to a variety of tumor diseases.Therefore, Single nucleotide polymorphism of n WISP1 gene may be a common genetic factor affecting individual cancer susceptibility.To date, only a few studies have investigated the relationship between n WISP1 gene and cervical cancer.Therefore, this article reviews the research progress of n WISP1 gene and cervical cancer.n