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为了探讨肺癌与微量元素之间的关系 ,采用PE30 30型原子吸收分光光度计对 30 0例肺癌、50例肺良性疾病患者及 10 0名健康成人的血清进行了铜、锌、铁、锰、钙水平及铜 /锌比值的测定。结果单因素分析表明 ,肺癌组、肺良性疾病组血清铜、锰的水平及铜 /锌比值均明显高于健康对照组 ,而锌和钙则明显低于健康对照组 ,差异显著 (分别P <0 .0 5～ 0 .0 1)。肺癌与肺良性疾病组之间比较 ,被测的元素及铜 /锌比值均无明显的变化 (P >0 .0 5)。 3组组内受检者职业、居住地、年龄段被测元素及铜 /锌比值比较无明显的变化 (P >0 .0 5)。结果还表明 ,60例化疗的肺癌患者缓解组血清铜水平及铜 /锌比值与治疗前比较明显下降 ,而锌、钙上升 ,未缓解组的铜 /锌比值与治疗前比较明显上升 ,差异有非常显著性(分别P <0 .0 1)。非条件logistic多因素分析表明 ,肺癌患者血清钙的比数比为 0 .9950 ,95%CI为0 .9910～ 0 .9990 ;铜 /锌比值的比数比为 7.9914,95%CI为 3.4 310～ 18.6134 ;提示血清钙可能是肺癌发病的一个保护因素 ;而铜 /锌比值可能是个危险因素。结果还提示 ,以健康对照组铜 /锌比值 1.10为界值 ,对肺癌诊断阳性率为 68% ;并对肺癌的疗效评价有一定参考价值。
To investigate the relationship between lung cancer and trace elements, the serum of 300 lung cancer patients, 50 patients with benign lung disease, and 100 healthy adults were subjected to copper, zinc, iron, manganese, using a PE30 30 atomic absorption spectrophotometer. Determination of calcium levels and copper/zinc ratios. Results Univariate analysis showed that serum copper and manganese levels and copper/zinc ratio were significantly higher in the lung cancer group and benign lung disease group than in the healthy control group, while zinc and calcium were significantly lower than those in the healthy control group, with significant differences (P < 0 .0 5 to 0 .0 1). In comparison between lung cancer and benign lung disease groups, the measured elements and copper/zinc ratio did not change significantly (P > 0.05). There were no significant changes in the measured elements and copper/zinc ratio among occupations, places of residence, and age groups of subjects in the three groups (P > 0.05). The results also showed that the serum copper and copper/zinc ratios of the remission group in 60 patients with chemotherapy were significantly lower than those before treatment, while those of zinc and calcium were increased. The ratio of copper/zinc in the unreduced group was significantly higher than before treatment. Very significant (P < 0.01). Unconditional logistic multivariate analysis showed that the ratio of serum calcium in lung cancer patients was 0. 9950, 95% CI was 0. 9910 to 0. 9990, the ratio of copper/zinc ratio was 7.9914, and 95% CI was 3.4 310. ~ 18.6134; suggesting that serum calcium may be a protective factor for the development of lung cancer; and the copper/zinc ratio may be a risk factor. The results also suggested that the ratio of copper/zinc ratio of 1.10 in the healthy control group was the cut-off value, and the positive rate of lung cancer diagnosis was 68%; it had certain reference value for the evaluation of the efficacy of lung cancer.