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目的 探讨舒张早期二尖瓣血流E波速度在负荷改变及缺血状态下的变化规律。方法 在犬应用脉冲波多普勒测量左室对照状态、负荷改变及缺血状态下二尖瓣瓣尖及瓣下 1cm及2cm三个取样点的E波流速 ,各点心电图R波顶峰至E波顶峰的时间 (R E)变化 ,同时用心导管法测量左室松弛时间常数 (T) ,分析各指标的变化规律并了解与T值变化之间的关系。结果 二尖瓣血流速度在左室内的衰减为非线性 ,与静息状态相比速度衰减幅度由 2 5 %增加到 39% ,二尖瓣血流时间指标R E受负荷影响小 ,受缺血的影响显著与静息状态相比缺血状态下 ,R E1从 30 8ms± 5 4ms延长至 370ms± 74ms(P <0 0 1) ,R E2 从 318ms± 5 6ms延长至 397ms± 79ms(P <0 0 1)。结论 舒张早期二尖瓣血流E波速度受负荷改变影响、缺血可使其衰减加快。
Objective To investigate the changes of E-wave velocities in early diastolic mitral flow during changes of load and ischemia. Methods In dogs, pulse wave Doppler was used to measure the E wave velocity in three control points: the left ventricular control, the change of load and the three cusps of mitral valve and 1cm and 2cm under the ischemic condition. At the same time, the left ventricular relaxation time constant (T) was measured by cardiac catheterization, and the change rule of each index was analyzed and the relationship with the change of T value was also analyzed. Results The attenuation of mitral flow velocity in the left ventricle was non-linear, and the amplitude of mitral attenuation was increased from 25% to 39% compared with resting state. The mitral flow time index RE was less affected by the load and was affected by ischemia Compared with resting state, R E1 was prolonged from 30 8ms ± 5ms to 370ms ± 74ms (P <0.01) and R E2 was prolonged from 318ms ± 5 6ms to 397ms ± 79ms (P < 0 0 1). Conclusion Early diastolic mitral flow E wave velocity is affected by changes in load, ischemia can make its attenuation accelerated.