骨形态发生蛋白(BMP)是明确具有诱导成骨作用的生长因子。其通过结合靶细胞表面受体,活化细胞内一系列Sm ad蛋白,经Sm ad蛋白介导,将信号转导至细胞核内,在一系列辅助因子的作用下,启动成骨基因的表达。细胞内源性Smurf1对这一整个过程起抑制作用。本文就Smurf1调节因子在骨形态发生蛋白诱导骨生成中的作用做一综述。 Bone morphogenetic protein (BMP) is a clear growth factor that induces osteogenesis. It binds to target cell surface receptors and activates a series of Sm-adrenoceptors in cells, which are mediated by Sm-ad protein and transduce signals into the nucleus. Under the action of a series of cofactors, osteoblast genes are activated. Endogenous cell-derived Smurf1 inhibits this entire process. This article reviews the role of Smurf1 regulators in bone morphogenetic protein-induced osteogenesis.