以廉价的CuBr2为催化剂,发展了一种通过芳胺、乙醛酸酯与丙酮酸酯三组分反应制得喹啉-2,4-二羧基衍生物的简便有效方法.该方法具有很好的原子经济性,使用了便宜的催化剂和易得的试剂,在温和的条件下解决了以往喹啉-2,4-二羧基衍生物合成条件苛刻、产率低等问题,在生物活性分子和药物分子合成上有潜在的应用价值. With cheap CuBr2 as a catalyst, a simple and effective method for the preparation of quinoline-2,4-dicarboxy derivatives by the reaction of aromatic amines, glyoxylates and pyruvate is developed. The method is very good Of the atomic economy, the use of cheap catalysts and readily available reagents, under mild conditions to solve the previous quinoline-2,4-dicarboxy derivatives harsh synthetic conditions, low yields and other issues in the bioactive molecules and Synthesis of drug molecules have potential application value.