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目的探讨抗高血压治疗预防脑卒中的形态学机制。方法采用易卒中型肾血管性高血压大鼠口服美托洛尔治疗，观察抗高血压治疗各级脑动脉和心室壁厚度的形态学改变。结果治疗组大鼠血压仅短期轻度低于未治疗的高血压对照组，但治疗组各级脑动脉损害和左心室肥厚明显改善，脑卒、中发生率也显著低于高血压对照组。结论美托洛尔抗高血压治疗预防脑卒中的效果，不单纯由血压下降决定，还与其具有保护脑血管和逆转心室肥厚等作用有关。
Objective To investigate the morphological mechanism of stroke prevention by antihypertensive treatment. Methods Metoprolol was administered orally in rats with stroke-induced renovascular hypertension to observe the morphological changes of cerebral arteries and ventricular wall thickness at various stages of antihypertensive treatment. Results In the treatment group, the blood pressure of the rats in the treatment group was only slightly lower than that of the untreated hypertension group in the short term. However, the levels of cerebral arterial lesions and left ventricular hypertrophy in the treatment group were significantly improved. The incidence of stroke and stroke was also significantly lower than that of the hypertension control group. Conclusions The effect of metoprolol antihypertensive therapy in prevention of stroke is not only determined by the decrease of blood pressure, but also by its function of protecting cerebrovascular and reversing ventricular hypertrophy.