论文部分内容阅读
1968年曾发现维生素 D 是在肝脏经羟化作用转变为具有较强生物活性的25-OH-D_3。以后不久又发现,25-OH-D_3可被位于肾脏的另一羟化酶系催化,在甲状旁腺素(PTH)的调节下转变为生物活性更强的1,25-(OH)_2-D_3,后者可促进小肠对于钙的转运和吸收,并具有增加钙结合蛋白(Ca-BP)生物合成的作用。作为一种激素,1,25-(OH)_2-D_3同类固醇激素的作用方式相同,是通过作用于骨、小肠等靶器官的细胞核
In 1968, vitamin D was found to be converted into 25-OH-D_3 with strong bioactivity in the liver through hydroxylation. Shortly thereafter, it was also found that 25-OH-D_3 is catalyzed by another hydroxylase located in the kidney and converted to a more bioactive 1,25- (OH) 2-phosphate by the regulation of parathyroid hormone (PTH) D_3, which promotes small intestine calcium transport and absorption, and has the effect of increasing calcium-binding protein (Ca-BP) biosynthesis. As a hormone, 1,25- (OH) _2-D_3 acts the same way with steroid hormones by acting on the nuclei of target organs such as bone and small intestine