论文部分内容阅读
多少年来,许多药物曾用于治疗肺结核病,但在1940年以前,始终没有发现一种确实有效而无严重毒性的药物。1940年发见了碸类(promin),证明对豚鼠的结核病有效,这是化学疗法之开端。至1944年发现链霉素以后,过去许多绝望的结核病如结核性脑膜炎等,得到了救治;也大大地促进了肺结核外科疗法之安全及发展。尤其是1952年发现异菸肼以后,肺结核之治疗,就进入了化学疗法时代。化学疗法(以下简称化疗)变得愈来愈重要,已成为肺结核治疗上之基础,使休息营养方法、萎陷疗法、及疗养院住院治疗等降为次要。由于化疗的显著疗效,使世界各国的结核病死亡率在近去十年中,减少了75％左右。发病率在有些国家虽然没有死亡率那样显著,但也降低了。由此我们可以看出,化疗在近十年来延长了许多结核病人的寿命,挽救了千百方人之生命。化疗的临床疗效是很显著的,根据美国复员军人会医院3300人试验之
For many years many drugs have been used to treat tuberculosis, but until 1940, never found a truly effective and without serious toxicity of drugs. In 1940 we met the promin, which proved to be effective against tuberculosis in guinea pigs, which is the beginning of chemotherapy. After the discovery of streptomycin in 1944, many desperate tuberculosis such as tuberculous meningitis in the past have been treated and the safety of tuberculosis surgical treatment has been greatly promoted. In particular, the discovery of isoniazid in 1952, the treatment of tuberculosis, entered the era of chemotherapy. Chemotherapy (hereinafter referred to as chemotherapy) has become increasingly important and has become the basis for the treatment of tuberculosis, rest nutrition method, collapse therapy, and nursing home hospital treatment to secondary. Due to the significant effect of chemotherapy, the death rate of tuberculosis in countries in the world has been reduced by 75% in the past decade. Although the incidence is not as significant in some countries as mortality, it is also lower. From this we can see that chemotherapy has prolonged the life span of many TB patients in the past decade and saved thousands of lives. The clinical effect of chemotherapy is very significant, according to the United States Association for Demobilized soldiers will test 3300 people