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本文测定10例胰岛素依赖型糖尿病(IDDM)和30例正常对照组儿童的尿系列微量蛋白,发现IDDM患儿在尿微量白蛋白排量与正常对照组相同情况下,患儿尿视黄醇结合蛋白(RBP)排量((?)67.21μg/mmolCr)明显增高,与正常对照组((?)15.36μg/mmolCr)比较差异显著(P<0.01)。糖尿病尿RBP排量与血浆果糖胺值呈显著正相关(P<0.01)。尿RBP排量与血清C肽浓度无相关,提示尿RBP是一项较尿微量白蛋白更敏感的糖尿病肾病的早期诊断指标。
In this study, urine microalbuminuria was measured in 10 children with insulin-dependent diabetes mellitus (IDDM) and 30 normal controls. It was found that urinary albumin excretion in urine of patients with IDDM was significantly higher than that of controls (RBP) (67.21μg / mmolCr) was significantly higher than that of the normal control group (15.36μg / mmolCr) (P <0.01). Diabetic urine RBP displacement and plasma fructosamine value was significantly correlated (P <0.01). Urinary RBP volume and serum C-peptide concentration had no correlation, suggesting that urinary RBP is a more sensitive indicator of urinary microalbuminuria in diabetic nephropathy.