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长期服用乙胺丁醇可致眼和全身中毒反应,主要表现为球后视神经炎、视乳气炎和网膜出血,偶有胃肠障碍、肝功异常、下肢发麻及过敏反应。笔者曾遇2例视神经萎缩者,现报导如下。例1:男,31岁。于1983年3月在某医院诊断左上肺浸润型肺结核,口服雷米封治疗。于1984年1月加服乙胺丁醇,每日一次,每次0.75克,连续服用8个月,于9月底突然视力下降,右0.3,左0.3,又10天后双眼视力下降至0.04,立即停服乙胺丁醇。患者曾到广州某医院门诊治疗5个月,视力无提高。于1988年3月26日来我院诊治,检查双眼视力均为0.04,视神经乳头边界清晰,乳头上血管数量减少,乳头呈苍白状,黄斑中心窝反光存在,网膜上未见出血。例2:男,36岁。于1984年初在某医院诊断右
Long-term use of ethambutol can cause eye and systemic toxic reactions, mainly manifested as retrobulbar neuritis, optic hyperostosis and omental bleeding, occasional gastrointestinal disorders, abnormal liver function, lower extremity numbness and allergic reactions. I have encountered two cases of optic nerve atrophy who are reported as follows. Example 1: Male, 31 years old. In March 1983 in a hospital diagnosis of upper left pulmonary tuberculosis, oral Remy Seal treatment. In January 1984 plus ethambutol, 0.75 g once daily for 8 months, sudden visual loss at the end of September, right 0.3, left 0.3, and 10 days later binocular vision decreased to 0.04, immediately Stop taking ethambutol. Patients have been to a hospital in Guangzhou for 5 months treatment, no improvement of visual acuity. March 26, 1988 came to our hospital for diagnosis and treatment, check both eyes were 0.04 visual acuity, clear boundary of the optic nerve nipple, the number of blood vessels on the nipple decreased, the nipple was pale, macular foveal reflex exists, no omentum bleeding. Example 2: Male, 36 years old. In the beginning of 1984, a hospital diagnosed right