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目的通过对黄埔区孕妇唐氏综合征筛查与产前诊断结果分析,了解其在临床的实际应用价值。方法对2009年1月-2011年12月共4187例孕妇进行孕中期唐氏综合征筛查,计算唐氏综合征风险率,高风险者建议抽羊水进行产前诊断。结果筛查出高风险孕妇206例,阳性率为4.92%,其中150例进行了产前诊断,发现7例染色体异常胎儿。结论通过孕中期唐氏综合征筛查,对高风险孕妇进行产前诊断,可早发现、早干预,对减少缺陷儿出生有积极意义。
Objective To investigate the screening and prenatal diagnosis of Down’s syndrome in pregnant women in Huangpu district and to find out its practical value in clinic. Methods From January 2009 to December 2011 a total of 4187 pregnant women in the second trimester of Down’s syndrome screening to calculate the risk of Down Syndrome, high risk of amniotic fluid recommendations for prenatal diagnosis. Results A total of 206 high risk pregnant women were screened out, with a positive rate of 4.92%. Among them, 150 cases were diagnosed prenatally and 7 cases were found to have chromosomal abnormalities. Conclusion Through the screening of Down’s syndrome during the second trimester, prenatal diagnosis of high-risk pregnant women can be early detection and early intervention, to reduce the birth of defective children have a positive meaning.