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目的 了解慢性胃炎患儿空腹及餐后部分胃肠激素的变化情况,深入探讨其病理生理学变化。方法 应用放射免疫分析法检测30例慢性胃炎患儿及20例健康儿童空腹及餐后1h外周血部分胃肠激素水平。结果 空腹:慢性胃炎组胃泌素为156.61±45.65pg/ml,胃动素为239.30±73.59pg/ml,生长抑素为106.38±72.03pg/ml;健康对照组依次为:124.92±50.25pg/ml,326.31±58.23pg/ml,68.13±37.65pg/ml。慢性胃炎组血清胃泌素和血浆胃动素较健康对照组有显著变化(P<0.05),而血浆生长抑素两组无统计学差异(P>0.05)。餐后:慢性胃炎组胃泌素176.64±25.25pg/ml,胃动素274.32±102.91pg/ml,生长抑素143.55±60.96pg/ml;健康对照组依次为:137.22±59.64pg/ml,373.93±139.93pg/ml,102.72±41.82pg/ml。与对照组比较,慢性胃炎组血清胃泌素和血浆生长抑素均显著增高(P<0.05);但两组胃动素无统计学意义(P>0.05)。餐前餐后比较:两组胃泌素、胃动素、生长抑素餐后较餐前有所增高,但前两者增高无显著差异(P>0.05),生长抑素增高两组均有显著差异(P<0.05)。结论 慢性胃炎患儿血胃泌素、胃动素及生长抑素水平异常,提示这些胃肠激素的改变可能参与其病理生理变化。
Objective To understand the changes of fasting and postprandial part of gastrointestinal hormones in children with chronic gastritis and to explore the pathophysiological changes. Methods The levels of some gastrointestinal hormones in peripheral blood of 30 children with chronic gastritis and 20 healthy children were detected by radioimmunoassay. Results Fasting: the gastrin in chronic gastritis group was 156.61 ± 45.65pg / ml, the motilin was 239.30 ± 73.59pg / ml, the somatostatin was 106.38 ± 72.03pg / ml; the healthy control group was 124.92 ± 50.25pg / ml, 326.31 ± 58.23 pg / ml, 68.13 ± 37.65 pg / ml. Serum gastrin and plasma motilin in chronic gastritis group had significant changes compared with healthy control group (P <0.05), but there was no significant difference between plasma somatostatin groups (P> 0.05). After meal, gastrin in chronic gastritis group was 176.64 ± 25.25pg / ml, motilin was 274.32 ± 102.91pg / ml, somatostatin was 143.55 ± 60.96pg / ml, and healthy control group was 137.22 ± 59.64pg / ml, 373.93 ± 139.93 pg / ml, 102.72 ± 41.82 pg / ml. Compared with the control group, serum gastrin and plasma somatostatin in chronic gastritis group were significantly increased (P <0.05), but there was no significant difference between the two groups (P> 0.05). Pre and postprandial comparison: The levels of gastrin, motilin and somatostatin in the two groups were higher than those before meals, but there was no significant difference between the two groups (P> 0.05). Somatostatin increased in both groups Significant difference (P <0.05). Conclusion The abnormal levels of blood gastrin, motilin and somatostatin in children with chronic gastritis suggest that the changes of these gastrointestinal hormones may be involved in the pathophysiological changes.