目的探讨树鼠句对TTV的易感性。方法通过股静脉将TTV接种于树鼠句并设对照组。用PCR技术检测血清及肝组织中TTV_DNA ,并用全自动分析仪进行DNA序列分析。结果在4只接种了TTV的树鼠句中 ,2只(50 %)血清ALT异常升高 ,肝组织有炎症表现 ,同时血清及肝组织均检出TTV -DNA ,这些检出物的序列与接种物TTV完全一致。结论树鼠句对TTV是敏感的,有望建成TTV感染的树鼠句动物模型。 Objective To investigate the susceptibility of tree rat to TTV. Methods The TTV was inoculated into the tree rat by femoral vein and the control group was established. TTV_DNA in serum and liver tissue was detected by PCR and DNA sequence analysis was performed by automatic analyzer. Results Twenty-five (50%) of the rats that were inoculated with TTV were abnormally elevated in serum ALT, liver tissues showed inflammation, and TTV-DNA was detected in serum and liver tissues. The sequences of these detected products Inoculum TTV exactly the same. Conclusion Squirrel sentence is sensitive to TTV and it is expected to build an animal model of TTV infection.