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婴儿猝死综合征(SIDS)的发病率为1.43～2.7‰活产新生儿。发病机理不明,可能与病毒感染而诱发的肺内异常免疫反应有关。作者应用单克隆抗体检测了SIDS患儿肺泡灌洗细胞的表型,并测定灌洗上清液中的白细胞介素-2(IL-2),以了解是否有免疫调控障碍参入本病的发生。病人、方法和结果来自1986年南澳大利亚某儿童医院的16例疑诊死于SIDS婴儿(年龄1～7月)为研究组,4例死于急性非呼吸道疾病的婴儿(年龄1～32月)为对照组。尸解完整地取出肺脏,经气管内导管用37℃生理盐水灌洗,收集灌洗液离心获得细胞,并根据吉姆萨染色的形态及酸性磷酸酶的有无来确定细胞类型。二组细胞总数及类型无明显差异。
The incidence of sudden infant death syndrome (SIDS) was 1.43 ~ 2.7 ‰ live births. The pathogenesis is unknown, which may be related to abnormal lung immune response induced by virus infection. The authors used monoclonal antibodies to detect the phenotypes of alveolar lavage cells in children with SIDS and determined interleukin-2 (IL-2) levels in the lavage supernatant to see if immune-mediated disorders are involved in the pathogenesis of this disease . The patients, methods and results were from 16 suspected daughters (from January to July) in a childrens hospital in South Australia in 1986 and 4 from infants (aged from January to March) who died of acute non-respiratory illness For the control group. The autopsy was removed completely from the lungs, lavaged with saline at 37 ° C via an endotracheal tube, and the cells were collected by centrifugation of the lavage fluid and cell types were determined according to the Giemsa-stained morphology and the presence or absence of acid phosphatase. There was no significant difference between the two groups in total number and type of cells.