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近年来,人们对肿瘤的基因治疗研究已取得了重大进展,其中,对共刺激分子基因治疗的研究成为近几年来的热门课题之一。共刺激分子主要有B7、ICAM-1、LFA-3和VCAM-1等,而B7分子是1982年Clark等人在研究B细胞分化表面标志时发现的一种主要表达于活化B细胞表面的蛋白分子。随着B7分子研究的深入,人们知道B7是淋巴细胞活化所需的最重要且最具代表性的共刺激分子之一。肿瘤细胞表面往往缺乏或低表达B7分子,从而逃过免疫监视得以生长。针对这个现象,人们采
In recent years, great progresses have been made in the research on gene therapy of tumors. Among them, the research on gene therapy of costimulatory molecules has become one of the hot topics in recent years. Costimulatory molecules are mainly B7, ICAM-1, LFA-3 and VCAM-1, etc., while B7 molecule is a protein mainly expressed on the surface of activated B cells discovered by Clark et al. In 1982 when studying B cell differentiation surface markers molecular. With the deepening of B7 molecular research, it is known that B7 is one of the most important and representative costimulatory molecules required for lymphocyte activation. Tumor cell surface often lack or low expression of B7 molecules, thus escaping immune surveillance to grow. In response to this phenomenon, people mining