论文部分内容阅读
对42例晚期肾衰病人在两种情况下作了血清红细胞生成素(S_(EP))的浓度测定:(1)第一次血液透析前作;(2)在定期血液透析治疗开始后3～37个月作。尽管每例红细胞压积(Hct)均上升,但S_(EP)浓度却减少。平均Hct由21.7升至28.6％(V/V)(P<0.001);S_(EP)由509降至182mU/ml(P<0.001)。这表明,贫血的改善并非红细胞生成素产生增加的结果,而很可能是由于血液透析治疗除掉了骨髓抑制物。S_(EP)浓度减少应被看成是与提高了红细胞压积有关的组织供氧改善的反应,或是肾脏病变加重,肾实质更形减少的结果。
In 42 patients with advanced renal failure, serum erythropoietin (S_ (EP)) concentrations were determined in two cases: (1) before the first hemodialysis; (2) 37 months for the work. Despite the increase in hematocrit (Hct) per case, the concentration of S_ (EP) decreased. The average Hct increased from 21.7 to 28.6% (V / V) (P <0.001); the S EP decreased from 509 to 182 mU / ml (P <0.001). This suggests that improvement of anemia is not the result of increased production of erythropoietin but is most likely due to hemodialysis treatment which removes myelosuppression. The decrease in the concentration of EP should be seen as a response to improved hematocrit-related tissue oxygenation or as a result of a more severe renal disease and a more reduced renal parenchyma.