目的研究死亡受体(Fas)和Fas死亡结构域蛋白(FADD)在帕金森病(PD)动物模型不同时相的表达及时程的变化,探讨Fas和FADD在PD发病机制中的作用。方法将40只大鼠随机分为正常对照组(n=8)、假手术组(n=8)和PD模型组(n=24)。PD模型组又均分为PD1、PD2和PD4三个亚组(分别为1周、2周和4周)。检测各组酪氨酸羟化酶(TH)阳性细胞数和Fas、FADD的表达情况。结果模型组TH阳性细胞数均明显减少,Fas和FADD在黑质区域的表达均明显高于正常对照组(P<0.01),但在PD1、PD2和PD4组间无统计学差异(P>0.05)。结论Fas和FADD在黑质纹状体中的持续异常表达可能在PD发病机制中起着重要的作用。 Objective To investigate the expression of Fas and Fas death domain proteins (FADD) in different phases of Parkinson’s disease (PD) and to explore the role of Fas and FADD in the pathogenesis of PD. Methods Forty rats were randomly divided into normal control group (n = 8), sham operation group (n = 8) and PD model group (n = 24). PD model group were divided into three subgroups: PD1, PD2 and PD4 (1 week, 2 weeks and 4 weeks respectively). The positive cells of tyrosine hydroxylase (TH) and the expression of Fas and FADD in each group were detected. Results The number of TH positive cells in model group was significantly decreased, while the expression of Fas and FADD in substantia nigra was significantly higher than that in normal control group (P <0.01), but there was no significant difference between PD1, PD2 and PD4 groups (P> 0.05 ). Conclusions The persistent abnormal expression of Fas and FADD in nigrostriatum may play an important role in the pathogenesis of PD.