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天然免疫系统是宿主抵御病原入侵的第一道防线,在机体抗感染免疫中发挥重要作用。Toll样受体(Toll-like receptors,TLRs)是天然免疫系统最重要的模式识别受体(pattern recognitionreceptors,PRRs)之一,通过识别病原真菌的病原相关分子模式(pathogen-associated molecularpatterns,PAMPs),招募特异接头蛋白,激活一系列信号级联反应,引发炎症因子、趋化因子等的释放和树突状细胞(dendritic cells,DCs)的成熟,发挥抗真菌感染作用。通过简要介绍宿主的TLRs及信号通路的研究进展,总结了目前TLRs对不同病原真菌PAMPs的天然免疫识别及信号通路研究现状,以期对进一步研究宿主天然免疫系统与病原真菌相互作用的分子机制提供参考。
The natural immune system is the host’s first line of defense against pathogen invasion and plays an important role in the anti-infective immunity of the body. Toll-like receptors (TLRs) are one of the most important pattern recognition receptors (PRRs) in the innate immune system. By identifying pathogen-associated molecular patterns (PAMPs) of pathogenic fungi, The specific adapter protein is recruited to activate a series of signal cascade reactions, triggering the release of inflammatory factors, chemokines and the like and the maturation of dendritic cells (DCs) to exert anti-fungal infection. By briefly introducing host TLRs and signaling pathways, the present status of innate immune recognition and signal pathway of TLRs against PAMPs of different pathogenic fungi is summarized, which will provide a reference for further study on the molecular mechanism of the interaction between host innate immune system and pathogenic fungi .