论文部分内容阅读
目的探讨多巴胺受体D2(DRD2)基因TaqI酶切位点多态性与帕金森病(Parkinson’s disease,PD)遗传易感性的关系。方法选择PD患者166例和正常对照170人,利用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术分析了TaqI位点A1/A1、A1/A2、A2/A2、B1/B1、B1/B2、B2/B2基因型在PD患者与正常对照组之间的分布情况。结果DRD2基因TaqI酶切位点在总体PD患者和总体对照组之间的分布差异无统计学意义(P>0.05);根据发病年龄和性别分组后,不管是早发还是晚发PD患者,无论男性还是女性,PD组和对照组的基因型和等位基因频率的差异均无统计学意义(均P>0.05)。结论DRD2基因TaqI多态性与PD的遗传易感性无关。
Objective To investigate the relationship between polymorphism of TaqI site of dopamine D2 receptor (DRD2) gene and the genetic predisposition of Parkinson ’s disease (PD). Methods Sixty-six patients with PD and 170 normal controls were selected. The alleles of A1 / A1, A1 / A2, A2 / A2 and B1 / A1 were analyzed by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) B1, B1 / B2, B2 / B2 genotypes in patients with PD and the distribution of the normal control group. Results There was no significant difference in the distribution of TaqI site of DRD2 gene between the overall PD patients and the control group (P> 0.05). According to the age and gender of the patients, PD patients with either early or late PD There was no significant difference in genotype and allele frequencies between PD group and control group (P> 0.05). Conclusion The TaqI polymorphism of DRD2 gene has nothing to do with the genetic predisposition of PD.