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最近已有报道用伊曲康唑治疗由犬小孢子菌所致的头癣有效。为进一步观察伊曲康唑的安全性和副作用,对伊曲康唑与灰黄霉素治疗头癣进行了双盲对比观察。 材料和方法:按随机双盲法将患者分成两组,分别与食物同时口服伊曲康唑100mg/d或灰黄霉素500mg/d,共6周。在治疗开始及治疗第2、4、6周和治疗结束后第2、4、8周进行临床评分和真菌学检查。治疗结束后第4、8周进行总的疗效评估。伊曲康唑组18例,女6例,男12例,除1例为成人外其余年龄均小于12岁;
More recently itraconazole has been reported to be effective in the treatment of tinea capitis caused by Microsporum canis. To further observe the safety and side effects of itraconazole, itraconazole and griseofulvin treatment of tinea capitis were double-blind comparison. MATERIALS AND METHODS: Patients were divided into two groups according to a randomized double-blind method: oral administration of itraconazole 100 mg / d or griseofulvin 500 mg / d respectively for 6 weeks. Clinical scores and mycological examinations were taken at the beginning of treatment and the second, fourth and sixth weeks of treatment and the second, fourth and eighth weeks after treatment. The 4th and 8th week after the treatment, the total curative effect was evaluated. Itraconazole group 18 cases, 6 females, 12 males, except for 1 case of adults, the remaining age were less than 12 years of age;