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为探索卵巢激素与乳腺癌的关系,作者在上海和洛杉矶同时进行年轻妇女乳腺癌的病例一对照研究。通过配对方法,对年龄、体重、身高、生育史和月经周期等因素作严格控制。本文包括上海的39例和洛杉矶的42例病灶局限的乳腺癌患者及其相同数量的健康妇女。用放免法定量测定月经周期第22天血清雌二醇(E_2)、性激素结合球蛋白(SHBG)和孕酮(Pg)的浓度。本文发现病例组E_2浓度高于对照组13％(P=0.038),E_2/SHBG比值上海高31.5％(P=0.020),洛杉矶的高24.8％(P=0.16)。洛杉矶对照的E_2浓度比上海对照高
To explore the relationship between ovarian hormones and breast cancer, the authors conducted a case-control study of breast cancer in young women in Shanghai and Los Angeles at the same time. Through the pairing method, the factors such as age, weight, height, birth history and menstrual cycle are strictly controlled. This article includes 39 cases of Shanghai and 42 cases of localized breast cancer in Los Angeles and the same number of healthy women. The levels of serum estradiol (E_2), sex hormone binding globulin (SHBG) and progesterone (Pg) were determined by radioimmunoassay on the 22nd day of the menstrual cycle. This study found that the E 2 concentration in case group was 13% higher than that in control group (P = 0.038). The E 2 / SHBG ratio in Shanghai was 31.5% higher (P = 0.020) and 24.8% higher in Los Angeles (P = 0.16). Los Angeles control E_2 concentration higher than the Shanghai control